FIGURE

Fig. 8

ID

ZDB-FIG-241126-46

Publication

Schmitner et al., 2024 - Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes

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Fig. 8

GKA Dorzagliatin does not induce oxidative stress in β-cells.

agck:GFP and EpRE:RFP expression in the endocrine islet (highlighted in white) of controls and pdx1^-/- treated with DMSO and GKA Dorzagliatin. Scale bar: 20 µm. b β-cells labeled with H2B-RFP in control and pdx1^-/- larvae treated with DMSO and Dorzagliatin. c The absolute β-cell numbers are unchanged upon treatment with Dorzagliatin in controls and pdx1^-/- (N > 3) as shown in a dot plot with indicated mean Statistical significance assessed by One-way ANOVA (<0.0001), P-values of multiple comparisons are indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bns525Tg ml203Tg; ml204Tg pdx1^sa280/sa280; ml203Tg; ml204Tg pdx1^sa280/sa280; bns525Tg
Condition:	chemical treatment by environment: enzyme activator
Observed In:	islet reactive oxygen species pancreas reactive oxygen species pancreatic B cell
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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