FIGURE

Fig. 3

ID

ZDB-FIG-241126-41

Publication

Schmitner et al., 2024 - Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes

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Fig. 3

Gck:GFP indicates gck expression in islet cells.

a Most β-cells express gck:GFP (solid arrows) as observed in 5 dpf double transgenic gck:GFP;ins:dsRed larvae. b Immunohistochemistry reveals gck:GFP expression in all Somatostatin labeled islet cells (solid arrows) at 5 dpf. c At 5 dpf, gck:GFP expression is rarely observed in Glucagon expressing α-cells (as labeled by anti-gcg antibody, solid arrows). Open arrows highlight hormone producing cells lacking gck:GFP staining. Scale bar: 50 µm.

Expression Data

Genes:	DsRed GFP
Antibodies:	Ab1-gcg Ab3-sst
Fish:	m1018Tg; ml203Tg
Anatomical Terms:	islet pancreatic A cell pancreatic B cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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