FIGURE

Fig. 1

ID

ZDB-FIG-241126-39

Publication

Schmitner et al., 2024 - Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes

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Fig. 1

Gck isoforms and their expression in the zebrafish.

a Genomic structure of the zebrafish gck gene and the three transcript isoforms. Exons are indicated by black rectangles and introns by lines, curved arrows represent the sites of transcription initiation. b Quantification of overall gck RNA counts from sorted adult zebrafish pancreatic cells (N = 3 biological replicates)²⁸ and embryonic hepatocytes (N = 2 biological replicates for each time point)²⁹. Plot shows Min to Max. c Heat map showing gck isoform expression in sorted zebrafish pancreatic α-, β- and δ-cells and embryonic hepatocytes at 4–6 dpf using the same published datasets^28,29 and the improved zebrafish transcriptome annotation of Lawson et al.²⁶.

Expression Data

Gene:	gck
Fish:	WT
Anatomical Terms:	liver pancreatic A cell pancreatic B cell pancreatic D cell
Stage Range:	Day 4 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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