FIGURE

Fig. 4

ID

ZDB-FIG-241126-42

Publication

Schmitner et al., 2024 - Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes

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Fig. 4

Gck:GFP recapitulates gck expression and nutrient responses in the liver.

Transgenic gck:GFP expression in the liver (yellow outline) at 4 dpf (a), 5 dpf (b) and unfed 6 dpf larvae (c). gck:GFP expression in the liver is nutrient dependent after depletion of the yolk, showing low expression upon fasting or minimal diet from 6 to 10 dpf (d) and significantly elevated expression upon feeding a high fat diet (HFD) from 6 to 10 dpf (e). Scale bar: 200 µm. f Quantification of GFP signal in the liver of MIN and HFD fed larvae (N = 8). Dot and bar plot showing mean with SD. Statistical significance assessed by Mann–Whitney-test.

Expression Data

Gene:	GFP
Fish:	ml203Tg
Conditions:	limited food availability high fat
Anatomical Term:	liver
Stage Range:	Day 4 to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ml203Tg
Condition:	limited food availability
Observed In:	liver
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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