FIGURE

Fig. 6

ID

ZDB-FIG-241126-44

Publication

Schmitner et al., 2024 - Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes

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Fig. 6

Gck:GFP expression in the islet in pdx1^-/- diabetic larvae is reduced.

a, bgck:GFP and ins:dsRed labeled cells in the islets of 6 and 10 dpf control and pdx1^-/- after MIN and HFD diet. Scale bar 50 µm. c, d Relative quantification of gck:GFP expressing cells and ins:dsRed labeled β-cells in the islet of pdx1^-/- compared to controls at 6 dpf. Dot plots with indicated mean. Statistical significance assessed by t-test. e, f Relative quantification of gck:GFP expressing cells and ins:dsRed labeled β-cells in the islet of pdx1^-/- compared to controls at 10 dpf. Dot plots with indicated mean. Statistical significance assessed by Two-way ANOVA, P-values of multiple comparisons are indicated. gInsulin gene expression levels analyzed via RT-qPCR under MIN and HFD feeding (N > 3). Dot and bar plot shows mean with SD. Statistical significance assessed by Two-way ANOVA. P-values of multiple comparisons are indicated.

Expression Data

Gene:	ins
Fish:	WT pdx1^sa280/sa280
Conditions:	limited food availability high fat
Anatomical Term:	whole organism
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT pdx1^sa280/sa280 pdx1^sa280/sa280; m1018Tg; ml203Tg
Conditions:	limited food availability high fat
Observed In:	pancreatic B cell whole organism
Stage Range:	Day 6 to Days 7-13

Phenotype Detail

Acknowledgments

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