ZFIN is now using GRCz12tu for Genomic Data

Gene

ins

ID

ZDB-GENE-980526-110

Name

preproinsulin

Symbol

ins Nomenclature History

Previous Names

insa (1)
zgc:109842

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable hormone activity and insulin receptor binding activity. Acts upstream of or within several processes, including negative regulation of feeding behavior; positive regulation of pancreatic A cell differentiation; and type B pancreatic cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blood plasma; dermal bone; digestive system; endocrine cell; and endoderm. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

349 figures from 211 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109842 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ins Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
maturity-onset diabetes of the young type 10	Alliance	Maturity-onset diabetes of the young, type 10	613370
type 1 diabetes mellitus 2	Alliance	Diabetes mellitus, insulin-dependent, 2	125852
		Diabetes mellitus, permanent neonatal 4	618858
		Hyperproinsulinemia	616214

Associated With ins Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022353	Insulin, conserved site
Domain	IPR016179	Insulin-like
Family	IPR004825	Insulin
Homologous_superfamily	IPR036438	Insulin-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Insulin	Insulin, conserved site	Insulin-like	Insulin-like superfamily
UniProtKB:B2GSI0	InterPro	108
UniProtKB:O73727	InterPro	108

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ins-201 (1) Ensembl	Ensembl		485 nt	Select Tool ZFIN BLAST
mRNA	ins-202 (1) Ensembl	Ensembl		331 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Host Organism	Assay	Source	Citations
Ab2-ins	polyclonal	ins	Guinea pig	IHC	Biomeda Corporation	7
Ab6-ins	polyclonal	ins	Guinea pig	IHC	Abcam plc	3
Ab1-ins	polyclonal	ins	Guinea pig	IHC	Dako North America, Inc.	37
Ab3-ins	polyclonal	ins	Guinea pig	IHC	Millipore	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations