Gene
ins
- ID
- ZDB-GENE-980526-110
- Name
- preproinsulin
- Symbol
- ins Nomenclature History
- Previous Names
-
- insa (1)
- zgc:109842
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity and insulin receptor binding activity. Acts upstream of or within several processes, including negative regulation of feeding behavior; positive regulation of pancreatic A cell differentiation; and type B pancreatic cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blood plasma; dermal bone; digestive system; endocrine cell; and endoderm. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 349 figures from 211 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109842 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| maturity-onset diabetes of the young type 10 | Alliance | Maturity-onset diabetes of the young, type 10 | 613370 |
| type 1 diabetes mellitus 2 | Alliance | Diabetes mellitus, insulin-dependent, 2 | 125852 |
| Diabetes mellitus, permanent neonatal 4 | 618858 | ||
| Hyperproinsulinemia | 616214 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin | Insulin, conserved site | Insulin-like | Insulin-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:B2GSI0 | InterPro | 108 | ||||
| UniProtKB:O73727 | InterPro | 108 |
Interactions and Pathways
Plasmids
No data available