| ZFIN ID: ZDB-EXP-250625-2 |
Experiment Conditions Description: chemical treatment by environment: dorzagliatin
| chemical treatment by environment: dorzagliatin |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | dorzagliatin |
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| Synonyms: | (2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide, dorzagliatin, dorzagliatina, dorzagliatine, dorzagliatinum, HMS 5552, HMS-5552, HMS5552, HuaTangNing |
| Definition: | A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methylpentanoic acid with the amino group of (2R)-3-(3-amino-1H-pyrrol-1-yl)propane-1,2-diol. It is an allosteric glucokinase activator developed by Hua Medicine for the treatment of type 1 and 2 diabetes mellitus , and diabetic kidney disease. |
| Ontology: | ChEBI [CHEBI:234514] ( EBI ) |
| Publication: | Schmitner et al., 2024 |
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