Search Ontology:
ChEBI
dorzagliatin
- Term ID
- CHEBI:234514
- Synonyms
-
- (2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide
- dorzagliatin
- dorzagliatina
- dorzagliatine
- dorzagliatinum
- HMS 5552
- HMS-5552
- HMS5552
- HuaTangNing
- Definition
- A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methylpentanoic acid with the amino group of (2R)-3-(3-amino-1H-pyrrol-1-yl)propane-1,2-diol. It is an allosteric glucokinase activator developed by Hua Medicine for the treatment of type 1 and 2 diabetes mellitus , and diabetic kidney disease.
- References
-
- CAS:1191995-00-2
- DrugBank:DB15123
- KEGG:D11342
- PMCID:PMC11454996
- PMID:29707866
- PMID:34706161
- PMID:35067153
- PMID:35551292
- PMID:35551294
- PMID:36342518
- PMID:36449148
- PMID:36505359
- PMID:36566614
- PMID:36918550
- PMID:37385967
- PMID:37537410
- PMID:37777375
- PMID:38179187
- PMID:38203742
- PMID:38394489
- PMID:38460077
- PMID:38664885
- PMID:38691834
- PMID:38783768
- PMID:39211666
- PMID:39214626
- PMID:39580550
- PMID:39629068
- PMID:39817211
- PMID:40231509
- PMID:40239741
- PMID:40272935
- PMID:40560322
- Wikipedia:Dorzagliatin
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from dorzagliatin
Phenotype where environments contain dorzagliatin
Phenotype modified by environments containing dorzagliatin
Phenotype affecting dorzagliatin
Human Disease Model