FIGURE

Fig. 9

ID

ZDB-FIG-250602-14

Publication

Gupta et al., 2025 - Mutations in the microexon splicing regulator srrm4 have minor phenotypic effects on zebrafish neural development

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Fig. 9

Srrm4 G0 crispants display a reduced optic tectum neuropil phenotype not observed in stable mutants. a) Plot showing the mean percent size difference between crispant and control larvae within major brain divisions at 6 dpf. b) Dorsal view of maximum intensity projection of voxels showing a significant reduction in volume in srrm4 G0 crispant larvae at 6 dpf based on cluster analysis (fire). Gray staining shows pan-neuronal expression of elavl3. Anterior is to the top. Otn, optic tectum neuropil. Scale bar = 100 μm. c, d) Forest plots depicting random model meta-analyses of srrm4 morphometry experiments. c) srrm4 G0 crispant experiments and (d) and srrm4 stable mutant experiments. Details of conditions for each experiment are provided in Table 1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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