FIGURE

Fig. 8

ID

ZDB-FIG-250602-13

Publication

Gupta et al., 2025 - Mutations in the microexon splicing regulator srrm4 have minor phenotypic effects on zebrafish neural development

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Fig. 8

Srrm4 G0 crispants do not recapitulate morphant phenotypes. a, b) Maximum intensity projections of sagittal sections showing acetylated tubulin and Islet 1 antibody staining in trigeminal neurons of wild-type (a) and srrm4y712 homozygous mutants (b) at 30 hpf. Acetylated tubulin, in green, marks developing neurites and Islet 1, in red, marks trigeminal neuron cell bodies. c, d) srrm4 G0 crispant and Cas9-injected control larvae at 3 dpf showing overall body morphology. c) Cas9-injected larva and (d) srrm4 G0 crispant larva. Anterior is to the left in all panels. e) Hair cell numbers from 2 neuromasts per larva in Cas9-injected controls (ctrl) vs srrm4 G0 crispants (crsp) at 3 dpf. Each dot represents the number of hair cells from an individual neuromast. N = 38 larvae per group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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