FIGURE

Fig. 9

ID

ZDB-FIG-260311-276

Publication

Luo et al., 2025 - General transcription factor IIIAa regulates the transcription of somatic 5S rRNA and influences embryonic organ development in zebrafish

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Fig. 9

Mutations in gtf3aa disrupt metabolic pathways. A PCA of transcriptomic data from three gtf3aa^−/− mutants and three gtf3aa^+/+ larvae at 3 dpf. B Volcano plot of differential gene expression between gtf3aa^−/− and gtf3aa^+/+ larvae. C KEGG pathway enrichment showing downregulated pathways in gtf3aa^−/− mutants. D Heatmap of significantly downregulated genes in the PPAR signaling pathway in gtf3aa^−/− larvae. E, F Temporal expression of key metabolic genes in the PPAR pathway (acadl, cpt1b, cpt2, fads2, pdpk1a, scp2a, cd36, fabp6, and hmgcs1) from 1 to 6 dpf in gtf3aa^−/− compared to gtf3aa^+/+ larvae. β-actin was used as the reference gene

Expression Data

Genes:	acadl cd36 cpt1b cpt2 fabp6 fads2 hmgcs1 pdpk1a scp2a
Fish:	AB gtf3aa^{ihb950/ihb950} (AB)
Anatomical Term:	whole organism
Stage Range:	Prim-5 to Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gtf3aa^{ihb950/ihb950} (AB)
Observed In:	whole organism
Stage Range:	Long-pec to Day 6

Phenotype Detail

Acknowledgments

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