Gene

hmgcs1

ID

ZDB-GENE-040426-1042

Name

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

Symbol

hmgcs1 Nomenclature History

Previous Names

zgc:56481 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have hydroxymethylglutaryl-CoA synthase activity. Involved in embryonic viscerocranium morphogenesis; neural crest cell differentiation; and oligodendrocyte development. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin musculature; and yolk syncytial layer. Orthologous to several human genes including HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

29 figures from 17 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:56481 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hmgcs1 Human Ortholog

No data available

Associated With hmgcs1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR000590	Hydroxymethylglutaryl-coenzyme A synthase, active site
Domain	IPR013528	Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
Domain	IPR013746	Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain
Family	IPR010122	Hydroxymethylglutaryl-CoA synthase, eukaryotic
Homologous_superfamily	IPR016039	Thiolase-like

Domain Details Per Protein

Protein	Length	Hydroxymethylglutaryl-CoA synthase, eukaryotic	Hydroxymethylglutaryl-coenzyme A synthase, active site	Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain	Hydroxymethylglutaryl-coenzyme A synthase, N-terminal	Thiolase-like
UniProtKB:A0A0R4IQG1 InterPro	519
UniProtKB:A0A8M1PIL7 InterPro	526

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hmgcs1-201 (1) Ensembl	Havana	688 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hmgcs1-202 (1) Ensembl	Havana	643 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hmgcs1-203 (1) Ensembl	Havana	986 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hmgcs1-204 (1) Ensembl	Havana	3182 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations