Gene
hmgcs1
- ID
- ZDB-GENE-040426-1042
- Name
- 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
- Symbol
- hmgcs1 Nomenclature History
- Previous Names
-
- zgc:56481 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable hydroxymethylglutaryl-CoA synthase activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; erythrocyte development; and oligodendrocyte development. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin musculature; and yolk syncytial layer. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to several human genes including HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56481 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la027211Tg | Transgenic insertion | Unknown | Unknown | DNA | |
vu57 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR000590 | Hydroxymethylglutaryl-coenzyme A synthase, active site |
Domain | IPR013528 | Hydroxymethylglutaryl-coenzyme A synthase, N-terminal |
Domain | IPR013746 | Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain |
Family | IPR010122 | Hydroxymethylglutaryl-CoA synthase, eukaryotic |
Homologous_superfamily | IPR016039 | Thiolase-like |
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Domain Details Per Protein
Protein | Additional Resources | Length | Hydroxymethylglutaryl-CoA synthase, eukaryotic | Hydroxymethylglutaryl-coenzyme A synthase, active site | Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain | Hydroxymethylglutaryl-coenzyme A synthase, N-terminal | Thiolase-like |
---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IQG1 | InterPro | 519 | |||||
UniProtKB:A0A8M1PIL7 | InterPro | 526 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hmgcs1-201
(1)
|
Ensembl | 688 nt | ||
mRNA |
hmgcs1-202
(1)
|
Ensembl | 643 nt | ||
mRNA |
hmgcs1-203
(1)
|
Ensembl | 986 nt | ||
mRNA |
hmgcs1-204
(1)
|
Ensembl | 3,182 nt | ||
mRNA |
hmgcs1-205
(1)
|
Ensembl | 1,699 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | RP71-80A19 | ZFIN Curated Data | |
Encodes | cDNA | MGC:56481 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201085 (1) | 3198 nt | ||
Genomic | GenBank:BX322605 (1) | 131830 nt | ||
Polypeptide | UniProtKB:A0A8M1PIL7 (1) | 526 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | HMGCS1 | 5 | Amino acid sequence comparison (1) |
- Williams, M.B., Green, G.B., Palmer, J.W., Fay, C.X., Chehade, S.B., Lawrence, A.L., Barry, R.J., Powell, M.L., Harris, M.L., Watts, S.A. (2023) Replacement of Dietary Fish Protein with Bacterial Protein Results in Decreased Adiposity Coupled with Liver Gene Expression Changes in Female Danio rerio. Current developments in nutrition. 8:102057102057
- Zhang, A.N., Huang, C., Yan, L., Liu, X., Wang, F., Zhang, Z., Li, L., Zhang, C., Zhang, Q. (2023) Metabolic regulation and antihyperglycemic properties of diet-derived PGG through transcriptomic and metabolomic profiling. Food & function. 14(12):5620-5630
- Zhu, Y., Hu, J., Zeng, S., Gao, M., Guo, S., Wang, M., Hong, Y., Zhao, G. (2023) L-selenomethionine affects liver development and glucolipid metabolism by inhibiting autophagy in zebrafish embryos. Ecotoxicology and environmental safety. 252:114589114589
- Chen, S., Ye, W., Clements, K.D., Zan, Z., Zhao, W., Zou, H., Wang, G., Wu, S. (2022) Bacillus licheniformis FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation. International Journal of Molecular Sciences. 24(1):
- Dai, W., Wang, K., Zhen, X., Huang, Z., Liu, L. (2022) Magnesium isoglycyrrhizinate attenuates acute alcohol-induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress. Nutrition & metabolism. 19:23
- Gao, G., Guo, S., Zhang, Q., Zhang, H., Zhang, C., Peng, G. (2022) Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles. eLIFE. 11:
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Li, C., Wu, Y., Li, H., Wang, H., Liu, J.X. (2022) Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Fish physiology and biochemistry. 48(6):1571-1586
- Singh, M.K., Yadav, R., Bhaskar, A.K., Sengupta, S., Sachidanandan, C. (2022) A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(1):159246
- Xu, Y., Tian, J., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J., Li, M. (2022) Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Frontiers in endocrinology. 13:864631
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