FIGURE

Fig 8

ID

ZDB-FIG-241119-61

Publication

Coppola et al., 2024 - A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish

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Fig 8

Wnt signaling and Foxf1 require Nr2f1a to promote a surplus of cardiomyocytes.

A-D) Confocal images of hearts from untreated and BIO-treated WT and nr2f1a^-/-myl7:DsRed2-NLS embryos. E) The number of myl7:DsRed2-NLS⁺/Amhc⁺ cardiomyocytes in hearts of untreated and BIO-treated WT and nr2f1a^-/-myl7:DsRed2-NLS embryos. Untreated WT (n = 12); untreated nr2f1a^-/- (n = 7); treated WT (n = 11); treated nr2f1a^-/- (n = 10). F-I) Confocal images of hearts from uninjected and Foxf1 mRNA-injected WT and nr2f1a^-/-myl7:DsRed2-NLS embryos. J) The number of myl7:DsRed2-NLS⁺/Amhc⁺ cardiomyocytes in uninjected and Foxf1 mRNA-injected WT and nr2f1a^-/-myl7:DsRed2-NLS embryos. Uninjected WT (n = 7); Uninjected nr2f1a^-/- (n = 5); Inj. WT (n = 10); Injected nr2f1a^-/- (n = 5). Hearts are stained for DsRed-NLS (red) and Amhc (blue). Scale bars: 50 μm. Error bars in graphs indicate s.e.m. ** indicate P < 0.01. **** indicate P < 0.001. **** indicate P < 0.0001. ns indicates not a statistically significant difference.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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