FIGURE

Fig 7

ID

ZDB-FIG-241119-60

Publication

Coppola et al., 2024 - A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish

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Fig 7

Tcf7l1a limits the ability of Foxf1 to promote 3’reg1 reporter expression.

A-D) Confocal images of hearts from control, Foxf1 mRNA injected, XAV-treated, and Foxf1 mRNA injected plus XAV-treated 3’reg1:GFP embryos. E) The percentage of control, Foxf1 mRNA injected, XAV-treated, and Foxf1 mRNA injected plus XAV-treated 3’reg1:GFP embryos with atrial expression, pan-cardiac expression, and lacking expression. Control (n = 26); Foxf1 (n = 24); XAV n = 98; Foxf1-XAV (n = 103). F-I) Confocal images of hearts from control, Foxf1 mRNA injected, tcf7l1a mRNA injected, and Foxf1 mRNA and tcf7l1a mRNA co-injected 3’reg1:GFP embryos. J) The percentage of control, Foxf1 mRNA injected, tcf7l1a mRNA injected, and Foxf1 mRNA and tcf7l1a mRNA co-injected 3’reg1:GFP embryos with atrial expression, pan-cardiac expression, and lacking expression. Control (n = 39), Foxf1 (n = 34); tcf7l1a (n = 95); Foxf1-tcf7l1a (n = 51). K-N) Confocal images of hearts from control, dnFoxf1 mRNA injected, tcf7l1a MO injected, and Foxf1 mRNA and tcf7l1a MO co-injected 3’reg1:GFP embryos. O) The percentage of control, dnFoxf1 mRNA injected, tcf7l1a MO injected, and Foxf1 mRNA and tcf7l1a MO 3’reg1:GFP embryos with atrial expression, pan-cardiac expression, and lacking expression. Control (n = 27), dnFoxf1 (n = 102); Tcf7l1a-MO (n = 96); dnFoxf1-tcf7l1aMO (n = 100). Hearts are stained for 3’reg1:GFP (green), Vmhc (red), Amhc (blue)Scale bars: 50 μm. **** indicate P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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