ZFIN ID: ZDB-FIG-111025-26
Madelaine et al., 2011 - Partially redundant proneural function reveals the importance of timing during zebrafish olfactory neurogenesis. Development (Cambridge, England)   138(21):4753-4762 Full text @ Development
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Antibodies:
Fish:
Anatomical Terms:
Stage: Protruding-mouth
PHENOTYPE:
Fish:
Observed In:
Stage: Protruding-mouth

Fig. 8

The fasciculation of olfactory axons and organisation of proto-glomeruli are flawed in neurog1 mutant zebrafish embryos. (A-I) Confocal projections of immunolabelling against PCAM and SV2 of olfactory projections in wild-type (A-C) and neurog1 mutant (D-I) embryos at 72 hpf. Whereas projections in wild-type embryos form a single fasciculated tract from the olfactory placode to the olfactory bulb, fasciculation (arrowheads in D,F) is aberrant in neurog1 mutant embryos; certain mutant embryos display abnormal guidance of projections immediately after they leave the placode (arrows in G,I). (J-O) Confocal projections of immunolabelling against PCAM and SV2 in the olfactory bulb in wild-type (J-L) and neurog1 mutant (M-O) embryos at 72 hpf. Proto-glomeruli appear less well organised in neurog1 mutant embryos relative to wild-type siblings. Embryos are viewed frontally (A-I) or dorsally with anterior up (J-O). Scale bars: 10 μM.

Gene Expression Details No data available
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab-SV2 IHC neurog1hi1059Tg/hi1059Tg standard conditions Protruding-mouth glomerular layer
IHC sb1Tg standard conditions Protruding-mouth glomerular layer
Ab1-ncam1b IHC neurog1hi1059Tg/hi1059Tg standard conditions Protruding-mouth primary olfactory fiber layer
IHC sb1Tg standard conditions Protruding-mouth primary olfactory fiber layer
Phenotype Details
Fish Conditions Stage Phenotype
neurog1hi1059Tg/hi1059Tg standard conditions Protruding-mouth axonal fasciculation disrupted, abnormal
Protruding-mouth glomerular layer morphology, abnormal
Protruding-mouth primary olfactory fiber layer morphology, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development