FIGURE

Figure 5

ID

ZDB-FIG-250127-192

Publication

Ren et al., 2024 - Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish

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Figure 5

Dhx38 regulates the alternative splicing of some genes involved in DNA damage repair: (A) Increased rate of transcripts with IR or ES among DNA repair in inner ears of dhx38 mutant embryos, as detected by PCR at 36 hpf. (B) The alternative splicing of these genes at 42 hpf. (C) The statistical data are presented as the mean ± SD of the PSI values at 36 hpf and 42 hpf from three biological replicates. PSI, percent splicing in. (D) The mRNA expression levels of some genes in inner ears of sibling and dhx38⁻^/− mutant embryos with DNA repair, as detected using RT-PCR. The data are presented as the mean ± SD. ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001.

Expression Data

Genes:	blm eme1 fanci foxm1 ints7 mms22l rad9a rad17 slx4 smc5 tonsl
Fish:	WT dhx38^hzu20/hzu20
Anatomical Term:	inner ear
Stage Range:	Prim-25 to High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dhx38^hzu20/hzu20
Observed In:	inner ear inner ear mRNA splicing, via endonucleolytic cleavage and ligation
Stage Range:	Prim-25 to High-pec

Phenotype Detail

Acknowledgments

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