FIGURE

Figure 3

ID

ZDB-FIG-231116-130

Publication

Finotto et al., 2023 - Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma

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Figure 3

Molecular heterogeneity of GBM‐associated macrophages

Principal component analysis (PCA) plot of macrophage population identified three distinct macrophage subclusters (MC1‐3). PCs were calculated using the 2,000 most variable genes. Plot shows PC1 and PC2.

Dot plot showing marker gene expression for immune‐stimulation and ‐suppression. Dot size indicates the percentage of cells in each macrophage subcluster expressing the gene, and dot color indicates the relative expression level.

Heatmap of top 25 differentially expressed genes in the macrophage subclusters, ranked by log₂(FC). Genes discussed in the text are highlighted in the subcluster colors.

Source data are available online for this figure.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.