FIGURE

Figure 3

ID

ZDB-FIG-230217-27

Publication

Panlilio et al., 2023 - Developmental exposure to domoic acid targets reticulospinal neurons and leads to aberrant myelination in the spinal cord

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Figure 3

DomA reduces the length and number of myelin sheaths produced by individual oligodendrocytes by 4 dpf. (A) Representative images of mosaically labeled oligodendrocytes in DomA-exposed (2 dpf injected) and control fish following 1–4 cell injections of the reporter construct, mbp:EGFP-CAAX into Tg(sox10:RFP) background. Only EGFP channel is presented to show the sparsely labeled myelin sheaths. Asterisks mark oligodendrocyte cell bodies. Peach arrow points to aberrant circular profiles. Scale bar = 50 μm. (B) Number of myelin sheaths produced by single oligodendrocytes (OL) in both control and DomA exposed fish. (C) Median length of the myelin sheaths produced by individual OLs in μm. OL without myelin sheaths were excluded from this graph. (D) Number of circular myelin membranes produced by individual OLs. ***p < 1 e−3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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