ZFIN Image: Panlilio et al., 2023, Figure 3

Image

Figure Caption

Figure 3

DomA reduces the length and number of myelin sheaths produced by individual oligodendrocytes by 4 dpf. (A) Representative images of mosaically labeled oligodendrocytes in DomA-exposed (2 dpf injected) and control fish following 1–4 cell injections of the reporter construct, mbp:EGFP-CAAX into Tg(sox10:RFP) background. Only EGFP channel is presented to show the sparsely labeled myelin sheaths. Asterisks mark oligodendrocyte cell bodies. Peach arrow points to aberrant circular profiles. Scale bar = 50 μm. (B) Number of myelin sheaths produced by single oligodendrocytes (OL) in both control and DomA exposed fish. (C) Median length of the myelin sheaths produced by individual OLs in μm. OL without myelin sheaths were excluded from this graph. (D) Number of circular myelin membranes produced by individual OLs. ***p < 1 e−3.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.