FIGURE

Fig. 9

ID
ZDB-FIG-220628-73
Publication
Deng et al., 2022 - Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism
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Fig. 9

RT-qPCR showed altered expression levels of neurogenesis-related markers in brsk2b–/– zebrafish. Human homologous protein: HOMER1, Homer Scaffold Protein 1, a postsynaptic density scaffolding protein; NRGN, Neurogranin, a postsynaptic protein kinase substrate; ISL1, a DNA-binding transcriptional activator; SOX2, a transcription factor regulating embryonic development and determining cell fate; NEUROG1, a transcriptional regulator involved in the initiation of neuronal differentiation; OLIG1, Oligodendrocyte Transcription Factor 1, promotes formation and maturation of oligodendrocytes; OLIG2, Oligodendrocyte Transcription Factor 2, required for oligodendrocyte and motor neuron specification in the spinal cord; SOX10, a transcription factor that plays a central role in developing and mature glia; MBP, a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system; MPZ, a major structural protein of the peripheral myelin sheath; PLP, a major myelin protein in central nervous system. n = 4 for each genotype, data for each gene are shown as mean ± SEM and compared with multiple t-tests. *p < 0.05, **p < 0.01.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.