Fig. 9

RT-qPCR showed altered expression levels of neurogenesis-related markers in brsk2b^–/– zebrafish. Human homologous protein: HOMER1, Homer Scaffold Protein 1, a postsynaptic density scaffolding protein; NRGN, Neurogranin, a postsynaptic protein kinase substrate; ISL1, a DNA-binding transcriptional activator; SOX2, a transcription factor regulating embryonic development and determining cell fate; NEUROG1, a transcriptional regulator involved in the initiation of neuronal differentiation; OLIG1, Oligodendrocyte Transcription Factor 1, promotes formation and maturation of oligodendrocytes; OLIG2, Oligodendrocyte Transcription Factor 2, required for oligodendrocyte and motor neuron specification in the spinal cord; SOX10, a transcription factor that plays a central role in developing and mature glia; MBP, a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system; MPZ, a major structural protein of the peripheral myelin sheath; PLP, a major myelin protein in central nervous system. n = 4 for each genotype, data for each gene are shown as mean ± SEM and compared with multiple t-tests. *p < 0.05, **p < 0.01.