FIGURE

Fig. 2

ID

ZDB-FIG-220628-66

Publication

Deng et al., 2022 - Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism

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Fig. 2

Generation of brsk2b mutant zebrafish. (A) Sanger sequencing and computational modeling of wild-type and mutant brsk2b in zebrafish. (B) The protein structures of brsk2b before and after variation by CRISPR/Cas9. (C) RT-qPCR showed a decrease in brsk2b mRNA expression in brsk2b mutant zebrafish (n = 4 for each genotype, p < 0.0001). (D) RT-qPCR showed no significant difference in brsk2a mRNA expression level between wild-type and brsk2b mutant zebrafish (n = 4 for each genotype, p = 0.847). Groups were statistically compared using an unpaired Student’s t-test. Data are shown as mean ± SEM, ****p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.