FIGURE

Fig. 3

ID

ZDB-FIG-220628-67

Publication

Deng et al., 2022 - Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism

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Fig. 3

brsk2b-deficient zebrafish displayed developmental delay. (A) Lateral images of brsk2b^+/+, brsk2b^±, brsk2b^–/– larvae at 1, 2, 3 dpf. Scale bars 500 μm. (B) The optic tectum (OT) and body length (L) were measured from lateral and dorsal images using ImageJ. The red line represents OT, and the blue lines represent body length. (C–E) The body lengths of brsk2b^–/– larvae at 2 dpf (C), 3 dpf (D), 5 dpf (E) were significantly shorter than that of brsk2b^+/+ larvae (n = 24 for each genotype, p = 0.0001, 0.0001, and 0.0043, respectively). (F) The values of OT of brsk2b^–/– larvae at 5 dpf were smaller compared to that of brsk2b^+/+ larvae (n = 24 for each genotype, p = 0.0001). (G) The ratio of OT/L in three genotypes didn’t show significant difference at 5 dpf (brsk2b^+/+: brsk2b^±: brsk2b^–/– = 24: 23: 22, p = 0.385). Groups were compared using a one-way ANOVA followed by a Dunnett’s multiple comparisons test. Data are shown as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.