ZFIN ID: ZDB-FIG-181024-16
Xu et al., 2018 - Fox proteins are modular competency factors for facial cartilage and tooth specification. Development (Cambridge, England)   145(12) Full text @ Development
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage Range: High-pec to Protruding-mouth
PHENOTYPE:
Fish:
Observed In:
Stage Range: Protruding-mouth to Day 5

Fig. S6

Expression of foxc1a in sox9a mutants and chondrocyte defects in Fox-C mutants

(A) Expression of foxc1a in the first two arches is unchanged in sox9a mutants at 42hpf.

(B) Confocal imaging of chondrocytes labeled by col2a1:mCherry-NTR (red) and osteoblasts labeled by sp7:GFP (green) at 72 hpf. In foxc1a; foxc1b mutants, col2a1:mCherry-NTR expression is weaker and/or reduced in the palatoquadrate (Pq), symplectic (Sy), and hyosymplectic (Hm) domains. sp7:GFP+ osteoblasts of the developing opercular bone (Op, arrows) are less affected. Numbers indicate proportion of animals showing the displayed patterns. Scale bars = 100 μm.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP b1212Tg; el559Tg standard conditions Protruding-mouth opercle osteoblast IFL
foxc1ael543/el543; foxc1bel620/el620; b1212Tg; el559Tg standard conditions Protruding-mouth opercle osteoblast IFL
foxc1a WT standard conditions High-pec pharyngeal arch 1 ISH
High-pec pharyngeal arch 2 ISH
sox9atw37/tw37 standard conditions High-pec pharyngeal arch 1 ISH
High-pec pharyngeal arch 2 ISH
mCherry b1212Tg; el559Tg standard conditions Protruding-mouth hyosymplectic cartilage chondrocyte IFL
Protruding-mouth palatoquadrate cartilage chondrocyte IFL
Protruding-mouth symplectic chondrocyte IFL
foxc1ael543/el543; foxc1bel620/el620; b1212Tg; el559Tg standard conditions Protruding-mouth hyosymplectic cartilage chondrocyte IFL
Protruding-mouth palatoquadrate cartilage chondrocyte IFL
Protruding-mouth symplectic chondrocyte IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
foxc1ael543/el543; foxc1bel620/el620 standard conditions Day 5 pectoral fin skeleton morphology, normal
foxc1ael543/el543; foxc1bel620/el620; b1212Tg; el559Tg standard conditions Protruding-mouth hyosymplectic cartilage chondrocyte mCherry expression decreased amount, abnormal
Protruding-mouth palatoquadrate cartilage chondrocyte mCherry expression decreased amount, abnormal
Protruding-mouth symplectic chondrocyte mCherry expression decreased amount, abnormal
foxf1el658/el658; foxf2ael616/el616; foxf2bel621/el621 standard conditions Day 5 pectoral fin skeleton morphology, normal
Acknowledgments:
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