ZFIN Figure: Yee et al., 2011, Fig. 2

ZFIN ID: ZDB-FIG-111212-8

ZFIN ID: ZDB-FIG-111212-8

Yee et al., 2011 - Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Disease models & mechanisms 4(2):240-254 Full text @ Dis. Model. Mech.

ADDITIONAL FIGURES

PHENOTYPE:

Fish:	swd^p75fm/p75fm
Observed In:	epithelial cell of pancreas epithelial cell proliferation mitotic cell cycle
Stage Range:	Protruding-mouth to Day 5

Fig. 2

The swd^p75fm mutation impairs exocrine pancreatic epithelial cell division and cell growth. (A) Cell-cycle analysis of the exocrine pancreatic epithelia in swd^p75fm mutants and WT siblings at 72 hpf. % BrdU+ nuclei represent the proportion of cells in the S phase of the cell cycle. (B) Morphometric analysis of cell growth (area, in µm², per cell) in the exocrine pancreatic epithelia of swd^p75fm mutants and WT siblings on 3 and 5 dpf. Each value represents the mean + s.e.m. Statistical analysis was performed using Student’s t-test, with *P<0.05 considered statistically significant.

Gene Expression Details No data available

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
swd^p75fm/p75fm	standard conditions	Protruding-mouth	epithelial cell proliferation decreased occurrence, abnormal
		Protruding-mouth	mitotic cell cycle disrupted, abnormal
		Protruding-mouth - Day 5	epithelial cell of pancreas decreased area, abnormal

Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.