ZFIN ID: ZDB-FIG-111212-8
Yee et al., 2011 - Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Disease models & mechanisms   4(2):240-254 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Protruding-mouth to Day 5

Fig. 2

The swdp75fm mutation impairs exocrine pancreatic epithelial cell division and cell growth. (A) Cell-cycle analysis of the exocrine pancreatic epithelia in swdp75fm mutants and WT siblings at 72 hpf. % BrdU+ nuclei represent the proportion of cells in the S phase of the cell cycle. (B) Morphometric analysis of cell growth (area, in µm2, per cell) in the exocrine pancreatic epithelia of swdp75fm mutants and WT siblings on 3 and 5 dpf. Each value represents the mean + s.e.m. Statistical analysis was performed using Student’s t-test, with *P<0.05 considered statistically significant.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
swdp75fm/p75fm standard conditions Protruding-mouth epithelial cell proliferation decreased occurrence, abnormal
Protruding-mouth mitotic cell cycle disrupted, abnormal
Protruding-mouth - Day 5 epithelial cell of pancreas decreased area, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.