ZFIN Morpholino: MO3-pkd2

Target Location

Genome Build: GRCz11Chromosome: 1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-pkd2

No data available

Phenotype

Phenotype resulting from MO3-pkd2

Phenotype	Fish	Figures
artery cilium decreased length, abnormal	AB + MO3-pkd2	Fig. S14 from Pala et al., 2019
blood vessel decreased diameter, abnormal	AB + MO3-pkd2	Fig. S13 from Pala et al., 2019
blood vessel cilium decreased amount, abnormal	hsc5Tg; pku6Tg + MO3-pkd2	Fig. 2 from Liu et al., 2019
blood vessel cilium decreased length, abnormal	hsc5Tg; pku6Tg + MO3-pkd2	Fig. 2 from Liu et al., 2019
brain hydrocephalic, abnormal	WT + MO3-pkd2	Fig. 6 from Sussman et al., 2014 Fig. 9 from Rothschild et al., 2011 Fig. 8 from Giamarchi et al., 2010 Fig. 4 from Feng et al., 2008

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Phenotype of all Fish created by or utilizing MO3-pkd2

Phenotype	Fish	Conditions	Figures
ventral wall of dorsal aorta runx1 expression decreased amount, abnormal	pkd2^{ouc2015/ouc2015} + MO3-pkd2	control	Fig. 3 from Liu et al., 2019
ventral wall of dorsal aorta runx1 expression decreased distribution, abnormal	pkd2^{ouc2015/ouc2015} + MO3-pkd2	control	Fig. 3 from Liu et al., 2019
hematopoietic progenitor cell differentiation decreased occurrence, abnormal	pkd2^{ouc2015/ouc2015} + MO3-pkd2	control	Fig. 3 from Liu et al., 2019
whole organism chromosome increased amount, abnormal	AB + MO3-pkd2	standard conditions	Fig. 8 from Aboualaiwi et al., 2014
brain hydrocephalic, abnormal	AB + MO3-pkd2	standard conditions	Fig. 4 from Feng et al., 2008

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Citations

Include unpublished citations

Djenoune, L., Mahamdeh, M., Truong, T.V., Nguyen, C.T., Fraser, S.E., Brueckner, M., Howard, J., Yuan, S. (2023) Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry. Science (New York, N.Y.). 379:717871-78
Padhy, B., Xie, J., Wang, R., Lin, F., Huang, C.L. (2022) Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease. Journal of the American Society of Nephrology : JASN. 33(8):1501-1516
Vignes, H., Vagena-Pantoula, C., Prakash, M., Fukui, H., Norden, C., Mochizuki, N., Jug, F., Vermot, J. (2022) Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis. Developmental Cell. 57(5):598-609.e5
Chen, S., Huang, L., Zhou, S., Zhang, Q., Ruan, M., Fu, L., Yang, B., Xu, D., Mei, C., Mao, Z. (2021) NS398 as a potential drug for autosomal-dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models. Journal of Cellular and Molecular Medicine. 25(20):9597-9608
Geng, F., Ma, J., Li, X., Hu, Z., Zhang, R. (2021) Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration. International Journal of Molecular Sciences. 22(8):
Jacinto, R., Sampaio, P., Roxo-Rosa, M., Pestana, S., Lopes, S.S. (2021) Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5. Frontiers in cell and developmental biology. 9:624531
Maerker, M., Getwan, M., Dowdle, M.E., McSheene, J.C., Gonzalez, V., Pelliccia, J.L., Hamilton, D.S., Yartseva, V., Vejnar, C., Tingler, M., Minegishi, K., Vick, P., Giraldez, A.J., Hamada, H., Burdine, R.D., Sheets, M.D., Blum, M., Schweickert, A. (2021) Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5. Nature communications. 12:5482
Metzner, A., Griffiths, J.D., Streets, A.J., Markham, E., Philippou, T., Van Eeden, F.J.M., Ong, A.C.M. (2020) A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2^-/- phenotype. Scientific Reports. 10:72
Verschuren, E.H.J., Rigalli, J.P., Castenmiller, C., Rohrbach, M.U., Bindels, R.J.M., Peters, D.J.M., Arjona, F.J., Hoenderop, J.G.J. (2020) Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(5):6382-6398
Arhatte, M., Gunaratne, G.S., El Boustany, C., Kuo, I.Y., Moro, C., Duprat, F., Plaisant, M., Duval, H., Li, D., Picard, N., Couvreux, A., Duranton, C., Rubera, I., Pagnotta, S., Lacas-Gervais, S., Ehrlich, B.E., Marchant, J.S., Savage, A.M., van Eeden, F.J.M., Wilkinson, R.N., Demolombe, S., Honoré, E., Patel, A. (2019) TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Nature communications. 10:2024

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