ZFIN ID: ZDB-LAB-091105-1
YJ Chuang Lab
PI/Director: Chuang, Yung-Jen
Contact Person: Chuang, Yung-Jen
Email: yjchuang@life.nthu.edu.tw
URL: http://myjchuang.wixsite.com/yjc-lab
Address: Department of Medical Science & Institute of Bioinformatics and Structural Biology National Tsing Hua University No. 101, Sec. 2, Kuang Fu Road Hsinchu, 30013 Taiwan
Country: Taiwan
Phone: 886-3-5742764
Fax: 886-3-5715934
Line Designation: nn

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Our research is focusing on the study of vascular biology.
Specifically, we are interested in understanding:
(1) the angiogenic cues during diseased state or development;
(2) the process of tissue repair and remodeling after traumatic injury;
(3) Regulation of tumor micro-environment and its role in combination treatment of targeted therapy, chemotherapy and radiotherapy.


Bohns, F.R., Shih, Y.R., Chuang, Y.J., Akhtar, R., Chen, P.Y. (2020) Influence of Prednisolone and Alendronate on the de novo Mineralization of Zebrafish Caudal Fin. JBMR plus. 5:e10435
Tang, C., Shen, C., Zhu, K., Zhou, Y., Chuang, Y.J., He, C., Zuo, Z. (2020) Exposure to the AhR agonist cyprodinil impacts the cardiac development and function of zebrafish larvae. Ecotoxicology and environmental safety. 201:110808
Liu, W., Wu, C.Y., Lu, M.J., Chuang, Y.J., Tsai, E.M., Leu, S., Lin, I.L., Ko, C.J., Chiu, C.C., Chang, W.T. (2020) The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling. Oxidative medicine and cellular longevity. 2020:5167292
Lin, M.H., Chou, H.C., Chen, Y.F., Liu, W., Lee, C.C., Liu, L.Y., Chuang, Y.J. (2018) Development of a rapid and economic in vivo electrocardiogram platform for cardiovascular drug assay and electrophysiology research in adult zebrafish. Scientific Reports. 8:15986
Shen, C., Zhou, Y., Ruan, J., Chuang, Y.J., Wang, C., Zuo, Z. (2018) Generation of a Tg(cyp1a-12DRE:EGFP) transgenic zebrafish line as a rapid in vivo model for detecting dioxin-like compounds. Aquatic toxicology (Amsterdam, Netherlands). 205:174-181
Chang, Z., Chen, P.Y., Chuang, Y.J., Akhtar, R. (2018) Zebrafish as a model to study bone maturation: Nanoscale structural and mechanical characterization of age-related changes in the zebrafish vertebral column. Journal of the Mechanical Behavior of Biomedical Materials. 84:54-63
Liu, F.Y., Hsu, T.C., Choong, P., Lin, M.H., Chuang, Y.J., Chen, B.S., Lin, C. (2018) Uncovering the regeneration strategies of zebrafish organs: a comprehensive systems biology study on heart, cerebellum, fin, and retina regeneration. BMC systems biology. 12:29
Wang, T.W., Chang, K.C., Chen, L.H., Liao, S.Y., Yeh, C.W., Chuang, Y.J. (2017) Effects of an injectable functionalized self-assembling nanopeptide hydrogel on angiogenesis and neurogenesis for regeneration of the central nervous system. Nanoscale. 9(42):16281-16292
Yang, C.H., Yeh, Y.J., Wang, J.Y., Liu, Y.W., Chen, Y.L., Cheng, H.W., Cheng, C.M., Chuang, Y.J., Yuh, C.H., Chen, Y.R. (2017) NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish. Scientific Reports. 7:5241
Lee, I.J., Yang, Y.C., Hsu, J.W., Chang, W.T., Chuang, Y.J., Liau, I. (2017) Zebrafish model of photochemical thrombosis for translational research and thrombolytic screening in vivo. Journal of biophotonics. 10(4):494-502
Liu, L.Y., Lin, M.H., Lai, Z.Y., Jiang, J.P., Huang, Y.C., Jao, L.E., Chuang, Y.J. (2016) Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. Journal of Biomedical Science. 23:59
You, M.S., Jiang, Y.J., Yuh, C.H., Wang, C.M., Tang, C.H., Chuang, Y.J., Lin, B.H., Wu, J.L., Hwang, S.L. (2016) A Sketch of the Taiwan Zebrafish Core Facility. Zebrafish. 13 Suppl 1:S24-9
Pan, A.I., Lin, M.H., Chung, H.W., Chen, H., Yeh, S.R., Chuang, Y.J., Chang, Y.C., Yew, T.R. (2016) Direct-growth carbon nanotubes on 3D structural microelectrodes for electrophysiological recording. The Analyst. 141(1):279-84
Lin, C., Lin, C.N., Wang, Y.C., Liu, F.Y., Chuang, Y.J., Lan, C.Y., Hsieh, W.P., Chen, B.S. (2014) The role of TGF-ß signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach. BMC systems biology. 8:116
Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
Lin, C., Lin, C.N., Wang, Y.C., Liu, F.Y., Chien, Y.W., Chuang, Y.J., Lan, C.Y., Hsieh, W.P., Chen, B.S. (2014) Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection. BMC systems biology. 8 Suppl 5:S6
Wang, Y.C., Tsai, I.C., Lin, C., Hsieh, W.P., Lan, C.Y., Chuang, Y.J., Chen, B.S. (2014) Essential Functional Modules for Pathogenic and Defensive Mechanisms in Candida albicans Infections. BioMed Research International. 2014:136130
Chen, Y.Y., Chao, C.C., Liu, F.C., Hsu, P.C., Chen, H.F., Peng, S.C., Chuang, Y.J., Lan, C.Y., Hsieh, W.P., and Wong, D.S. (2013) Dynamic Transcript Profiling of Candida albicans Infection in Zebrafish: A Pathogen-Host Interaction Study. PLoS One. 8(9):e72483
Wang, Y.C., Lin, C., Chuang, M.T., Hsieh, W.P., Lan, C.Y., Chuang, Y.J., and Chen, B.S. (2013) Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. BMC systems biology. 7:79
Huang, W.C., Yang, C.C., Chen, I.H., Liu, Y.M., Chang, S.J., and Chuang, Y.J. (2013) Treatment of Glucocorticoids Inhibited Early Immune Responses and Impaired Cardiac Repair in Adult Zebrafish. PLoS One. 8(6):e66613
Hsu, P.C., Chao, C.C., Yang, C.Y., Ye, Y.L., Liu, F.C., Chuang, Y.J., and Lan, C.Y. (2013) Diverse Hap43-independent functions of the Candida albicans CCAAT-binding Complex. Eukaryotic Cell. 12(6):804-15
Chen, I.H., Wang, H.H., Hsieh, Y.S., Huang, W.C., Yeh, H.I., and Chuang, Y.J. (2013) PRSS23 is essential for the Snail-dependent endothelial to mesenchymal transition during valvulogenesis in zebrafish. Cardiovascular research. 97(3):443-453
Kuo, Z.Y., Chuang, Y.J., Chao, C.C., Liu, F.C., Lan, C.Y., and Chen, B.S. (2013) Identification of Infection- and Defense-Related Genes via a Dynamic Host-Pathogen Interaction Network Using a Candida Albicans-Zebrafish Infection Model. Journal of Innate Immunity. 5(2):137-52
Wang, C.H., Chen, I.H., Kuo, M.W., Su, P.T., Lai, Z.Y., Wang, C.H., Huang, W.C., Hoffman, J., Kuo, C.J., You, M.S., and Chuang, Y.J. (2011) Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development. Developmental dynamics : an official publication of the American Association of Anatomists. 240(6):1412-1421
Kuo, M.W., Wang, C.H., Wu, H.C., Chang, S.J., and Chuang, Y.J. (2011) Soluble THSD7A Is an N-Glycoprotein That Promotes Endothelial Cell Migration and Tube Formation in Angiogenesis. PLoS One. 6(12):e29000
Huang, W.C., Hsieh, Y.S., Chen, I.H., Wang, C.H., Chang, H.W., Yang, C.C., Ku, T.H., Yeh, S.R., and Chuang, Y.J. (2010) Combined Use of MS-222 (Tricaine) and Isoflurane Extends Anesthesia Time and Minimizes Cardiac Rhythm Side Effects in Adult Zebrafish. Zebrafish. 7(3):297-304
Chao, C.C., Hsu, P.C., Jen, C.F., Chen, I.H., Wang, C.H., Chan, H.C., Tsai, P.W., Tung, K.C., Wang, C.H., Lan, C.Y., and Chuang, Y.J. (2010) Zebrafish as a Model Host for Candida albicans Infection. Infection and Immunity. 78(6):2512-2521