PUBLICATION
Essential Functional Modules for Pathogenic and Defensive Mechanisms in Candida albicans Infections
- Authors
- Wang, Y.C., Tsai, I.C., Lin, C., Hsieh, W.P., Lan, C.Y., Chuang, Y.J., Chen, B.S.
- ID
- ZDB-PUB-140513-96
- Date
- 2014
- Source
- BioMed Research International 2014: 136130 (Journal)
- Registered Authors
- Chuang, Yung-Jen
- Keywords
- none
- MeSH Terms
-
- Animals
- Bacterial Proteins/immunology
- Candida albicans/immunology*
- Candida albicans/pathogenicity
- Candidiasis/immunology*
- Candidiasis/microbiology*
- Host-Pathogen Interactions/immunology*
- Immunity, Innate/immunology*
- Signal Transduction/immunology
- Zebrafish/immunology*
- Zebrafish/microbiology*
- PubMed
- 24757665 Full text @ Biomed Res. Int.
Citation
Wang, Y.C., Tsai, I.C., Lin, C., Hsieh, W.P., Lan, C.Y., Chuang, Y.J., Chen, B.S. (2014) Essential Functional Modules for Pathogenic and Defensive Mechanisms in Candida albicans Infections. BioMed Research International. 2014:136130.
Abstract
The clinical and biological significance of the study of fungal pathogen Candida albicans (C. albicans) has markedly increased. However, the explicit pathogenic and invasive mechanisms of such host-pathogen interactions have not yet been fully elucidated. Therefore, the essential functional modules involved in C. albicans-zebrafish interactions were investigated in this study. Adopting a systems biology approach, the early-stage and late-stage protein-protein interaction (PPI) networks for both C. albicans and zebrafish were constructed. By comparing PPI networks at the early and late stages of the infection process, several critical functional modules were identified in both pathogenic and defensive mechanisms. Functional modules in C. albicans, like those involved in hyphal morphogenesis, ion and small molecule transport, protein secretion, and shifts in carbon utilization, were seen to play important roles in pathogen invasion and damage caused to host cells. Moreover, the functional modules in zebrafish, such as those involved in immune response, apoptosis mechanisms, ion transport, protein secretion, and hemostasis-related processes, were found to be significant as defensive mechanisms during C. albicans infection. The essential functional modules thus determined could provide insights into the molecular mechanisms of host-pathogen interactions during the infection process and thereby devise potential therapeutic strategies to treat C. albicans infection.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping