FIGURE

Figure 4

ID

ZDB-FIG-260413-108

Publication

Schmidt et al., 2026 - Dysregulated Protease Homeostasis Defines Primary FSGS

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Figure 4

SERPINA1 is expressed and secreted by podocytes. (A) SERPINA1 mRNA expression in cultured human podocytes. Expression is given as fold change over time compared with 0 hour. Expression levels are normalized to GAPDH. (B) SERPINA1 protein in supernatant of cultured human podocytes at 16 and 24 hours relative to 1 hour; n=3 independent experiments per group. (C) SERPINA1 protein in supernatant of cultured human podocytes at 1, 16, and 24 hours after treatment with DEPC water (control) or a with a PAR1 agonist; n=3 independent experiments per group. (D) SERPINA1 protein in supernatant of cultured human podocytes 24 hours after treatment with DEPC water (control) or with TGF-β1; n=8 independent experiments per group. All data shown as mean of fold change ±SD. **P < 0.01, ***P < 0.001. DEPC, diethyl pyrocarbonate; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PAR1, protease-activated receptor 1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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