FIGURE

Fig. 7

ID

ZDB-FIG-250602-27

Publication

Tian et al., 2025 - C-mannosyltransferase DPY19L1L-mediated Reissner Fiber formation is critical for zebrafish (Danio rerio) body axis straightening

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Fig. 7

Model of SCO-spondin and RF in control and dpy19l1l-deficient zebrafish. (Top) In wild-type spinal cord, DPY19L1L C-mannosylates SCO-spondin (purple), enabling RF formation via cilia-driven CSF flow. (Bottom) In dpy19l1l−/− mutants, nonglycosylated SCO-spondin (dark blue) fails to form RF, leading to body axis curvature. CSF-CN, CSF-contacting neuron.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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