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Fig. 7

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ZDB-IMAGE-250602-27
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Figures for Tian et al., 2025
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Figure Caption

Fig. 7 Model of SCO-spondin and RF in control and dpy19l1l-deficient zebrafish. (Top) In wild-type spinal cord, DPY19L1L C-mannosylates SCO-spondin (purple), enabling RF formation via cilia-driven CSF flow. (Bottom) In dpy19l1lāˆ’/āˆ’ mutants, nonglycosylated SCO-spondin (dark blue) fails to form RF, leading to body axis curvature. CSF-CN, CSF-contacting neuron.

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