FIGURE

Figure 4.

ID

ZDB-FIG-250320-8

Publication

Doan et al., 2025 - Dock1 functions in Schwann cells to regulate development, maintenance, and repair

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Figure 4.

Myelin maintenance defects arise and accumulate with age in Dock1 cKO mice. (A and B) TEM micrographs of control and MUT nerves at 12 mo with MUTs containing aberrant myelin (red arrows) and Remak (red arrowheads) phenotypes. The following higher-magnification TEM micrographs are from 12-mo-old Dock1 cKO nerves: (C) Degenerating myelin (red arrows) and a large-caliber (>1 μm) axon in a Remak bundle (red arrowhead); (D) Disorganized myelin sheath (red arrow); (E) Accumulations of myelin debris and degenerating sheaths (red arrows). (F) Regeneration clusters (red arrow). (G) Myelin outfoldings and abnormal wrapping (red arrow). (H) The percentage of axons with abnormalities, n = 4 mice, 4 images per nerve (control); 4 mice, 4 images per nerve (Dock1 cKO). Here, and in all figures, the X symbol in the graph denotes a data point corresponding to the representative image shown. (A–G) Scale bar = 2 µm. (H) Unpaired t test with Welch’s correction. **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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