FIGURE

Fig. 7

ID

ZDB-FIG-250218-50

Publication

Basol et al., 2024 - Loss of carbohydrate sulfotransferase 6 function leads to macular corneal dystrophy phenotypes and skeletal defects in zebrafish

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Fig. 7

Histopathology of the corneal tissue in the mutant zebrafish. Alcian blue/periodic acid–Schiff-stained eye sections of (A) wt, (B) chst6pd4/pd4, (C) chst6f42/f42, (D) chst6pd5/pd5, and (E) chst6f42/f42 are shown (n = 7). Left column: 10× overview, scale bars: 200 μm; middle column: 40× close-up overview, scale bars: 50 μm; right column: 100× zoom, scale bars: 20 μm. Serial sections were taken from each eye, and different slices were shown in the middle and right columns. Collagen in stroma is stained pink with periodic acid–Schiff, mucopolysaccharides are stained blue with alcian blue, and nucleus is stained light purple with hematoxylin. e, epithelium; s, stroma. White arrows indicate alcian blue-positive aggregates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chst6^ibg1/ibg1 (AB) chst6^ibg2/ibg2 (AB) chst6^ibg3/ibg3 (AB)
Observed In:	corneal epithelium corneal stroma corneal stroma posterior region Descemet's membrane
Stage:	Adult

Phenotype Detail

Acknowledgments

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