FIGURE

Fig. 8

ID

ZDB-FIG-231109-37

Publication

Liu et al., 2023 - Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

Graphical abstract summarizing the research findings.

PTEC-expressed PENK-A levels decreased with the loss of PTs after AKI. This decrease triggered an increase in H₂O₂ production, resulting in the expansion of RPC aggregation. This process occurred by upregulating tcf21 expression through remodeling of H3K4me3 in the tcf21 promoter. In the later stage of regeneration, as PTECs recovered, elevated penka expression suppressed the production of H₂O₂, facilitating the termination of kidney regeneration.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.