FIGURE

Fig. 7

ID

ZDB-FIG-220923-100

Publication

Bensimon-Brito et al., 2021 - Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish

Other Figures

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Fig. 7

Sequential in vivo measurements allow the observation of phenotype progression. (A) Experimental setup for the sequential monthly measurements (t1, t2, t3) performed with echocardiography in WT and alk5a^–/– in control conditions (n = 7 WT, n = 6 alk5a^–/–) and upon treatment with isoprenaline (+ISO; n = 7 WT, n = 7 alk5a^–/–). (B–F) Graphs showing changes in OFT (B) and AVC (C) regurgitation in WT and alk5a^–/– adult zebrafish untreated or treated with isoprenaline. (G–I) Zebrafish # 2, which displays the most pronounced increase in the regurgitation fraction in the OFT from t1 to t3 (G), presented an enlarged OFT lumen in some histological sections (H) but not in others (I). Scale bars: 1 mm (D–G), 400 µm (H, I).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tgfbr1a^{bns329/bns329}; s843Tg
Condition:	chemical treatment: isoprenaline
Observed In:	blood circulation
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cardiovasc. Res.