FIGURE

Fig. 9

ID

ZDB-FIG-210210-17

Publication

Cambier et al., 2020 - Spreading of a mycobacterial cell surface lipid into host epithelial membranes promotes infectivity

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Fig. 9

Model of PDIM spreading to promote virulence in the zebrafish hindbrain ventricle. Cholesterol-dependent PDIM spread into epithelial membranes prevents TLR/Myd88 detection at the site of infection. Bacteria then drive resident macrophages to produce CCL2 to recruit CCR2-positive permissive monocytes which go on to form early granulomas. PDIM continues to spread into host membranes throughout this process. In low cholesterol settings (statin treatment) PDIM does not spread as readily into epithelial membranes. TLR/Myd88-dependent recruitment of microbicidal monocytes occurs, which can then clear infecting mycobacteria. Figure created with BioRender.com.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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