FIGURE

Fig. 7

ID

ZDB-FIG-210210-14

Publication

Cambier et al., 2020 - Spreading of a mycobacterial cell surface lipid into host epithelial membranes promotes infectivity

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Fig. 7

PDIM spreading into epithelial membranes is required to evade microbicidal monocytes. (A) Mean monocyte recruitment at 3 hpi of the HBV with ~100 live, heat-killed, PFA treated, or PFA+GA treated wildtype (WT) or ~100 live or heat-killed ∆mmpL7 M. marinum. (B) Mean monocyte recruitment at 3 hpi of the HBV of wildtype or Myd88-depleted fish with ~100 live or PFA+GA treated wildtype M. marinum. Mean volume of wildtype M. marinum following co-infection with (C) wildtype M. marinum treated as in A or (D) live or PFA+GA treated wildtype M. marinum in wildtype or Myd88-depleted fish. (E) Mean bacterial volume 3 days following HBV infection of wildtype fish with ~100 M. marinum recoated with Native, DIM-depleted (DIM–), DIM– plus PDIM (+PDIM), or DIM– plus PDIF (+PDIF) lipids. (A)-(C) ordinary one-way ANOVA with Tukey’s multiple comparisons test with selected adjusted P values shown. (D) and (E) Kruskal-Wallis ANOVA for unequal variances with Dunn’s multiple comparisons test with selected adjusted P values shown. (A)-(E) representative of three separate experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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