FIGURE

Figure 5—figure supplement 1.

ID

ZDB-FIG-201223-59

Publication

Lee et al., 2020 - Neuropeptide VF neurons promote sleep via the serotonergic raphe

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Figure 5—figure supplement 1.

Sleep induced by optogenetic stimulation of NPVF neurons is abolished in <italic>npvf</italic> mutant animals.

Normalized locomotor activity (top) and sleep (bottom) of 5-dpf Tg(npvf:ReaChR-mCitrine) (gray and light blue) and non-transgenic sibling control (black and blue) animals before (Baseline) and during exposure to blue light (Stimulation) in npvf +/- (A) and npvf -/- (B) animals. Box plots quantify locomotor activity and sleep for each animal during optogenetic stimulation normalized to the baseline of all animals of the same genotype. Stimulation of NPVF neurons decreases locomotor activity and increases sleep compared to non-transgenic sibling controls in npvf +/- animals (A) but not in npvf -/- siblings (B). n = number of animals. ns p>0.05, *p<0.05, ***p<0.005, Mann-Whitney test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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