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ID

ZDB-FIG-200406-129

Publication

Almstedt et al., 2020 - Integrative discovery of treatments for high-risk neuroblastoma

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Fig. 1

Integrative discovery of treatments for high-risk neuroblastoma.

a Step 1: Data integration. We combined omics data from three cohorts of high-risk neuroblastoma (R2, TARGET and SEQC) to construct risk signatures, which were linked to pharmaco-transcriptomic (L1000) and drug target (STITCH) data, resulting in associations between disease signatures and therapeutic targets. b Step 2: Experimental evaluation. Using tumour cells from high-risk cases, we combine RNA sequencing, cell-based assays, and animal models to confirm targets.

Expression Data

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Phenotype Data

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Acknowledgments

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