FIGURE

Fig. 6

ID

ZDB-FIG-200406-134

Publication

Almstedt et al., 2020 - Integrative discovery of treatments for high-risk neuroblastoma

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Fig. 6

Targeting MAPK8 and CNR2 suppressed neuroblastoma xenografts in zebrafish.

a Workflow: patient-derived neuroblastoma cells were tagged with green fluorescent protein (GFP), sorted, and injected into the midbrain of 1-day post fertilization (dpf) zebrafish embryos. b Tumour localization 24 h following injection (n = 266) (mean, standard deviation). c 2 dpf zebrafish embryos were exposed to drug concentrations corresponding to IC20, IC50 or IC80. Toxicity was noted after 24h , and score between 0 (no toxicity, white) and 5 (instant, lethal toxicity, red). d Automated image-based assay of tumour growth in xenotransplanted zebrafish embryos. e Tumour area increase from 2 to 5 dpf (mean, standard deviation). f Representative image of the same zebrafish embryos before and after treatment.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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