FIGURE

Fig. 6

ID

ZDB-FIG-180827-18

Publication

Ferrero et al., 2018 - Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish

Other Figures

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Fig. 6

Adult MG Derive from Embryonic HSCs

(A) Transgenic lines used to address the MG potential of embryonic HSCs.

(B) GFP (left panel) and DsRed (middle panel) immunostaining performed on quadruple-transgenic adult brain sections. The right panel shows a merge of both fluorescent channels.

(C) Pooled data from two experiments showing the percent recombination among brain MG in control (left) and gata2b:Cre adult fish (right) (n = 6). Error bars represent mean ± SEM.

(D) Correlation and regression analysis (R² = 0.85) between the chimerism in brain MG and the WKM myeloid fraction. MG, microglia; WKM, whole-kidney marrow.

See also Figure S6.

Expression Data

Genes:	DsRedx EGFP
Fish:	gl22Tg; sd32Tg; sd5Tg; zd17Tg
Anatomical Term:	brain microglial cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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