FIGURE

Fig. 1

ID
ZDB-FIG-151229-2
Publication
Isaacman-Beck et al., 2015 - The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration
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Fig. 1

Regenerating Motor Axons Select Their Original Trajectory with High Fidelity

(A and B) A schematic (A) and in vivo imaging (B) demonstrate that zebrafish peripheral motor axons traverse a common path then diverge to innervate functionally distinct myotomal regions (dashed triangle, dorsal ROI; dashed boxes, nerve transection site; scale bar, 10 µm).

(C) By 48 hpt, dorsal axons regrow with great fidelity to the original trajectory (80% of fascicles that developed in the dorsal ROI regrew on the dorsal path; n = 14 larvae, 26 nerves; red arrowhead, misguided regrowth).

In (B) and (C), we omitted Tg(Xla.Tubb:DsRed) signal from the dorsal panel as expression in the spinal cord overwhelms the max projection image. The ventral panel shows expression from both transgenes.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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