FIGURE

Fig. S3

ID
ZDB-FIG-151229-11
Publication
Isaacman-Beck et al., 2015 - The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration
Other Figures
All Figure Page
Back to All Figure Page
Fig. S3

Lh3 modifies Collagens and is required for Col4a5 localization, related to figures 4 and 5

(A) Lh3 glycosylation sites are present in the three collagens that we tested for roles in motor axon regeneration (grey bars - schematic of protein; red stripes - putative lh3 modification sites).

(B) Tg(sox10:col4a5myc) is expressed diffusely throughout the cells in wild type siblings and associates with membranes, but in lh3 mutants

(C) Col4a5myc aggregates in large puncta in the cytoplasm (n > 10 embryos, 50 cells per condition; Scale bar = 5µm).

(D) col18a1 and col19a1 are not required to guide regenerating dorsal fascicles (n > 20 larvae, 200 nerves per condition).

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Neuron