ZFIN ID: ZDB-FIG-150413-2
Banerjee et al., 2015 - Zebrafish foxc1a drives appendage-specific neural circuit development. Development (Cambridge, England)   142:753-62 Full text @ Development
Anatomical Term:
Stage: Prim-5
Observed In:
Stage: Prim-5

Fig. 2

The p162 mutant phenotype is caused by a nonsense mutation in the foxc1a gene. (A,B) The G to A nucleotide mutation converts tryptophan at position 118 into a premature stop codon. (C) Conceptual translation of the foxc1ap162 predicts a 117 amino acid protein truncated within the forkhead (FH) domain. (D) Injection of wild-type foxc1a mRNA restores axon guidance in foxc1a mutants. (E) Quantification of the mRNA rescue. Numbers on top of individual bars indicate the number of hemisegments and embryos (brackets) analyzed. For all genotypes, only the first six anterior segments were analyzed. Scale bar: 10┬Ám in D.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP foxc1ap162/p162; ml2Tg standard conditions Prim-5 motor neuron axon IFL
ml2Tg standard conditions Prim-5 motor neuron axon IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
foxc1ap162/p162; ml2Tg standard conditions Prim-5 primary motor neuron axon guidance process quality, abnormal
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