ZFIN ID: ZDB-FIG-150413-3
Banerjee et al., 2015 - Zebrafish foxc1a drives appendage-specific neural circuit development. Development (Cambridge, England)   142:753-62 Full text @ Development
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Anatomical Terms:
Stage Range: Long-pec to Day 4
PHENOTYPE:
Fish:
Observed In:
Stage Range: Long-pec to Day 4

Fig. 3

foxc1a is required for fin-innervating motor nerves to convert at the plexus. (A) Lateral (composite) view of a 96-hpf-old Tg(mnx1:GFP) larvae expressing GFP in all motor nerves. Yellow dashed boxes mark anterior segments (AS) and posterior segments (PS) considered in this study; white dotted area outlines the pectoral fin. (B,C) Compared with wild-type larvae, trunk innervation (posterior segments) is unaffected in foxc1a mutants. (D-G) By contrast, three out of the four fin-innervating nerves in foxc1a mutants display axonal defects at 48hpf (D-G) and at 96hpf (H-K). Dotted areas outline the pectoral fin, arrowheads indicate the position of the fin plexus and arrows indicate the fourth pectoral fin nerve. Cyan asterisks indicate ectopic fasciculation; red asterisks mark defasciculation. Scale bars: 50┬Ám.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP foxc1ap162/p162; ml2Tg standard conditions Long-pec motor neuron axon IFL
Long-pec pectoral fin motor nerve IFL
Long-pec pectoral fin motor nerve axon IFL
Day 4 motor neuron IFL
Day 4 motor neuron axon IFL
Day 4 pectoral fin motor nerve 1 IFL
Day 4 pectoral fin motor nerve 1 axon IFL
Day 4 pectoral fin motor nerve 2 IFL
Day 4 pectoral fin motor nerve 2 axon IFL
Day 4 pectoral fin motor nerve 3 IFL
Day 4 pectoral fin motor nerve 3 axon IFL
Day 4 pectoral fin motor nerve 4 IFL
Day 4 pectoral fin motor nerve 4 axon IFL
ml2Tg standard conditions Long-pec motor neuron axon IFL
Long-pec pectoral fin motor nerve IFL
Long-pec pectoral fin motor nerve axon IFL
Day 4 motor neuron IFL
Day 4 motor neuron axon IFL
Day 4 pectoral fin motor nerve 1 IFL
Day 4 pectoral fin motor nerve 1 axon IFL
Day 4 pectoral fin motor nerve 2 IFL
Day 4 pectoral fin motor nerve 2 axon IFL
Day 4 pectoral fin motor nerve 3 IFL
Day 4 pectoral fin motor nerve 3 axon IFL
Day 4 pectoral fin motor nerve 4 IFL
Day 4 pectoral fin motor nerve 4 axon IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
foxc1ap162/p162; ml2Tg standard conditions Long-pec pectoral fin motor nerve 1 motor neuron axon guidance process quality, abnormal
Long-pec pectoral fin motor nerve 2 axon defasciculated, abnormal
Long-pec pectoral fin motor nerve 2 axon terminus mislocalised, abnormal
Long-pec pectoral fin motor nerve 2 motor neuron axon guidance process quality, abnormal
Long-pec pectoral fin motor nerve 3 axon defasciculated, abnormal
Long-pec pectoral fin motor nerve 3 axon terminus mislocalised, abnormal
Long-pec pectoral fin motor nerve 3 motor neuron axon guidance process quality, abnormal
Long-pec pectoral fin motor nerve 4 motor neuron axon guidance process quality, abnormal
Day 4 pectoral fin motor nerve 1 motor neuron axon guidance process quality, abnormal
Day 4 pectoral fin motor nerve 2 axon defasciculated, abnormal
Day 4 pectoral fin motor nerve 2 axon terminus mislocalised, abnormal
Day 4 pectoral fin motor nerve 2 motor neuron axon guidance process quality, abnormal
Day 4 pectoral fin motor nerve 3 axon defasciculated, abnormal
Day 4 pectoral fin motor nerve 3 axon terminus mislocalised, abnormal
Day 4 pectoral fin motor nerve 3 motor neuron axon guidance process quality, abnormal
Day 4 pectoral fin motor nerve 4 motor neuron axon guidance process quality, abnormal
Day 4 pectoral fin nerve axon terminus decreased amount, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development