ZFIN ID: ZDB-FIG-150413-1
Banerjee et al., 2015 - Zebrafish foxc1a drives appendage-specific neural circuit development. Development (Cambridge, England)   142:753-62 Full text @ Development
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Antibody:
Fish:
Anatomical Terms:
Stage: Prim-5
PHENOTYPE:
Fish:
Observed In:
Stage: Prim-5

Fig. 1

foxc1a guides primary motor axon selectively in anterior somite segments. (A) Lateral (composite) view of a 26-h-old Tg (mnx1:GFP) embryo expressing GFP in all motor neurons. White dashed boxes mark anterior somite segments (AS) and posterior segments (PS) considered in this study. Compared with wild type (B,D), foxc1a mutants (C,E) exhibit motor axon guidance defects selectively in anterior but not posterior somitic segments. (F-I) Somite polarity (F,G), as revealed by the localization of Engrailed-positive nuclei (arrows) towards the anterior somite boundary (dashed lines), and muscle differentiation (H,I), as revealed by the apposition of muscle AChRs with axons to form en passant synapses are unaffected in foxc1a mutants. Arrowheads indicate stalled and branched axons. Scale bars: 50µm in A; 10µm in B-I.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP foxc1ap162/p162; ml2Tg standard conditions Prim-5 motor neuron IFL
Prim-5 motor neuron axon IFL
Prim-5 motor neuron axon IHC
ml2Tg standard conditions Prim-5 motor neuron IFL
Prim-5 motor neuron axon IFL
Prim-5 motor neuron axon IHC
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-eng IHC foxc1ap162/p162 standard conditions Prim-5 muscle pioneer
IHC foxc1ap162/p162; ml2Tg standard conditions Prim-5 muscle pioneer
Phenotype Details
Fish Conditions Stage Phenotype
foxc1ap162/p162; ml2Tg standard conditions Prim-5 primary motor neuron axon guidance process quality, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development