|ZFIN ID: ZDB-FIG-120329-39|
ALK Inhibits a Developmentally-Timed Apoptotic Response Triggered by MYCN Overexpression in the Interrenal Gland (A) Numbers of Hu+ interrenal gland cells in the DβH, ALK, MYCN, and MYCN;ALK fish at 5.5 wpf. Means of Hu+ cell numbers were compared by the two-tailed Wilcoxon signed-rank test. (B) Numbers of apoptotic Hu+ interrenal gland cells in the DβH, ALK, MYCN, and MYCN;ALK fish at 5.5 wpf. The numbers of transgenic fish at 5.5 wpf with apoptotic Hu+ cells in the interrenal gland were compared by two-tailed Fisher exact test. (C) Sagittal sections through the interrenal gland in MYCN (top panels) and MYCN;ALK (bottom panels) transgenic fish at 5.5 wpf (dorsal up, anterior left). Hu, green; activated Caspase-3, red. Hu+, activated Caspase-3+ apoptotic cells were detected in the MYCN transgenic fish (arrowheads). Dotted lines indicate the head kidney (HK) boundary. Scale bars represent 10 μm. See also Figure S7.
|zdf16Tg (AB)||standard conditions||Days 30-44||interrenal gland neuroblast apoptotic, abnormal|
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Reprinted from Cancer Cell, 21(3), Zhu, S., Lee, J.S., Guo, F., Shin, J., Perez-Atayde, A.R., Kutok, J.L., Rodig, S.J., Neuberg, D.S., Helman, D., Feng, H., Stewart, R.A., Wang, W., George, R.E., Kanki, J.P., and Look, A.T., Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis, 362-373, Copyright (2012) with permission from Elsevier. Full text @ Cancer Cell