|ZFIN ID: ZDB-FIG-120329-36|
MYCN Expression Causes Sympathoadrenal Cell Loss (A) DβH transgenic line. Oblique views of dβh RNA expression (left panels); lateral views of EGFP expression in merged confocal-brightfield images (middle panels); dorsal views of th RNA expression (right panels). Arrows point to the SCG, and arrowheads point to the CG. Scale bar represents 100 μm. (B) MYCN transgenic line. MYCN expression causes loss of cells in the SCG (arrows). Scale bar represents 100 μm. (C) ALK transgenic line. ALK expression does not interfere with the SCG development (arrows). Scale bar represents 100 μm. (D) MYCN;ALK transgenic line. Loss of cells in the SCG is not rescued by activated ALK expression (arrows). Scale bar represents 100 μm. AAC, arch-associated catecholaminergic neurons; CG (arrowheads), cranial ganglia; DA, diencephalic dopaminergic neurons; e, ear; LC, locus coeruleus; MO, medulla oblongata; r, retina; SCG, superior cervical ganglion. See also Figure S4 and Table S1.
|zdf16Tg (AB)||standard conditions||Protruding-mouth||superior cervical ganglion absent, abnormal|
|zdf16Tg; zdf17Tg (AB)||standard conditions||Protruding-mouth||superior cervical ganglion absent, abnormal|
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Reprinted from Cancer Cell, 21(3), Zhu, S., Lee, J.S., Guo, F., Shin, J., Perez-Atayde, A.R., Kutok, J.L., Rodig, S.J., Neuberg, D.S., Helman, D., Feng, H., Stewart, R.A., Wang, W., George, R.E., Kanki, J.P., and Look, A.T., Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis, 362-373, Copyright (2012) with permission from Elsevier. Full text @ Cancer Cell