Gene
th
- ID
- ZDB-GENE-990621-5
- Name
- tyrosine hydroxylase
- Symbol
- th Nomenclature History
- Previous Names
-
- th1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables tyrosine 3-monooxygenase activity. Involved in dopamine biosynthetic process from tyrosine. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in perinuclear region of cytoplasm. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 275 figures from 139 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Segawa syndrome, recessive | 605407 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
Conserved_site | IPR021164 | Tyrosine hydroxylase, conserved site |
Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
Domain | IPR041903 | Tyrosine 3-monooxygenase, catalytic domain |
Family | IPR001273 | Aromatic amino acid hydroxylase |
Family | IPR005962 | Tyrosine 3-monooxygenase |
Family | IPR019773 | Tyrosine 3-monooxygenase-like |
Homologous_superfamily | IPR036329 | Aromatic amino acid monoxygenase, C-terminal domain superfamily |
Homologous_superfamily | IPR036951 | Aromatic amino acid hydroxylase superfamily |
Domain Details Per Protein
Protein | Length | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tyrosine 3-monooxygenase | Tyrosine 3-monooxygenase, catalytic domain | Tyrosine 3-monooxygenase-like | Tyrosine hydroxylase, conserved site |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6ZM47
|
408 | |||||||||
UniProtKB:A0A2R8RPJ0
|
505 | |||||||||
UniProtKB:Q9W7K7
|
110 | |||||||||
UniProtKB:B3DJW5
|
489 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA | ottdart00000002329 (1) | 1226 nt | |
mRNA |
th-201
(1)
|
1470 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
ab8-th | Rabbit |
|
1 | ||||
ab7-th | IgY | Chicken |
|
2 | |||
Ab5-th | monoclonal | IgG2a , k | Mouse |
|
Vector Laboratories
|
3 | |
Ab3-th | monoclonal | IgG1 , k | Mouse |
|
Millipore
Antibodies-online.com |
108 | |
Ab4-th | polyclonal | Rabbit |
|
Millipore
|
37 | ||
Ab1-th | monoclonal | IgG1 | Mouse |
|
ImmunoStar, Inc.
|
42 | |
Ab2-th | polyclonal | Rabbit |
|
Pel-Freez Biologicals
|
12 | ||
Ab6-th | polyclonal | Rabbit |
|
17 |
Plasmids