Gene

th

ID

ZDB-GENE-990621-5

Name

tyrosine hydroxylase

Symbol

th Nomenclature History

Previous Names

th1 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Enables tyrosine 3-monooxygenase activity. Involved in dopamine biosynthetic process from tyrosine. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in perinuclear region of cytoplasm. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

275 figures from 139 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With th Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Segawa syndrome, recessive	605407

Associated With th Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018301	Aromatic amino acid hydroxylase, iron/copper binding site
Conserved_site	IPR021164	Tyrosine hydroxylase, conserved site
Domain	IPR019774	Aromatic amino acid hydroxylase, C-terminal
Domain	IPR041903	Tyrosine 3-monooxygenase, catalytic domain
Family	IPR001273	Aromatic amino acid hydroxylase
Family	IPR005962	Tyrosine 3-monooxygenase
Family	IPR019773	Tyrosine 3-monooxygenase-like
Homologous_superfamily	IPR036329	Aromatic amino acid monoxygenase, C-terminal domain superfamily
Homologous_superfamily	IPR036951	Aromatic amino acid hydroxylase superfamily

Domain Details Per Protein

Protein	Length	Aromatic amino acid hydroxylase	Aromatic amino acid hydroxylase, C-terminal	Aromatic amino acid hydroxylase, iron/copper binding site	Aromatic amino acid hydroxylase superfamily	Aromatic amino acid monoxygenase, C-terminal domain superfamily	Tyrosine 3-monooxygenase	Tyrosine 3-monooxygenase, catalytic domain	Tyrosine 3-monooxygenase-like	Tyrosine hydroxylase, conserved site
UniProtKB:Q6ZM47 InterPro	408
UniProtKB:A0A2R8RPJ0 InterPro	505
UniProtKB:Q9W7K7 InterPro	110
UniProtKB:B3DJW5 InterPro	489

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	ottdart00000002329 (1)	1226 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	th-201 (1) Ensembl	1470 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
ab8-th		th th2		Rabbit	WB		1
ab7-th		th th2	IgY	Chicken	IHC WB		2
Ab5-th	monoclonal	th	IgG2a , k	Mouse	IHC	Vector Laboratories	3
Ab3-th	monoclonal	th	IgG1 , k	Mouse	IHC WB	Millipore Antibodies-online.com	108
Ab4-th	polyclonal	th th2		Rabbit	IHC WB	Millipore	37
Ab1-th	monoclonal	th	IgG1	Mouse	IHC WB	ImmunoStar, Inc.	42
Ab2-th	polyclonal	th		Rabbit	IHC	Pel-Freez Biologicals	12
Ab6-th	polyclonal	th		Rabbit	IHC		17

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations