Gene
th
- ID
- ZDB-GENE-990621-5
- Name
- tyrosine hydroxylase
- Symbol
- th Nomenclature History
- Previous Names
-
- th1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables tyrosine 3-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in neuron projection and perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; heroin dependence; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 317 figures from 171 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Segawa syndrome, recessive | 605407 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Conserved_site | IPR021164 | Tyrosine hydroxylase, conserved site |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041903 | Tyrosine 3-monooxygenase, catalytic domain |
| Domain | IPR049321 | Tyrosine 3-monooxygenase-like, ACT domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
| Family | IPR005962 | Tyrosine 3-monooxygenase |
| Family | IPR019773 | Tyrosine 3-monooxygenase-like |
| Homologous_superfamily | IPR036329 | Aromatic amino acid monoxygenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036951 | Aromatic amino acid hydroxylase superfamily |
| Homologous_superfamily | IPR045865 | ACT-like domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tyrosine 3-monooxygenase | Tyrosine 3-monooxygenase, catalytic domain | Tyrosine 3-monooxygenase-like | Tyrosine 3-monooxygenase-like, ACT domain | Tyrosine hydroxylase, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DJW5 | InterPro | 489 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000002329 (1) | Havana | 1,226 nt | ||
| mRNA |
th-201
(1)
|
Ensembl | 1,470 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| ab8-th | Rabbit |
|
1 | ||||
| ab7-th | IgY | Chicken |
|
3 | |||
| Ab5-th | monoclonal | IgG2a , k | Mouse |
|
Vector Laboratories
|
3 | |
| Ab3-th | monoclonal | IgG1 , k | Mouse |
|
Millipore
Antibodies-online.com |
119 | |
| Ab4-th | polyclonal | Rabbit |
|
Millipore
|
49 | ||
| Ab1-th | monoclonal | IgG1 | Mouse |
|
ImmunoStar, Inc.
|
50 | |
| Ab2-th | polyclonal | Rabbit |
|
Pel-Freez Biologicals
|
15 | ||
| Ab6-th | polyclonal | Rabbit |
|
20 |
Plasmids