Gene
th2
- ID
- ZDB-GENE-050201-1
- Name
- tyrosine hydroxylase 2
- Symbol
- th2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables tryptophan 5-monooxygenase activity. Involved in dopamine biosynthetic process from tyrosine. Acts upstream of or within dopamine biosynthetic process and serotonin biosynthetic process. Is expressed in head; kidney; liver; and nervous system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041903 | Tyrosine 3-monooxygenase, catalytic domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
| Family | IPR005962 | Tyrosine 3-monooxygenase |
| Family | IPR019773 | Tyrosine 3-monooxygenase-like |
| Homologous_superfamily | IPR036329 | Aromatic amino acid monoxygenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036951 | Aromatic amino acid hydroxylase superfamily |
Domain Details Per Protein
| Protein | Length | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tyrosine 3-monooxygenase | Tyrosine 3-monooxygenase, catalytic domain | Tyrosine 3-monooxygenase-like |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6IVB6
|
471 | ||||||||
|
UniProtKB:Q1LWZ5
|
471 | ||||||||
|
UniProtKB:Q5RHI3
|
475 |
Interactions and Pathways
No data available
Plasmids
No data available