Gene
th2
- ID
- ZDB-GENE-050201-1
- Name
- tyrosine hydroxylase 2
- Symbol
- th2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables tryptophan 5-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and serotonin biosynthetic process. Predicted to be located in neuron projection and perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in female organism; head; kidney; liver; and nervous system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 28 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-th2 | N/A | (2) |
| MO2-th2 | N/A | Ren et al., 2013 |
| MO3-th2 | N/A | Ren et al., 2013 |
| MO4-th2 | N/A | (2) |
| MO5-th2 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041903 | Tyrosine 3-monooxygenase, catalytic domain |
| Domain | IPR049321 | Tyrosine 3-monooxygenase-like, ACT domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tyrosine 3-monooxygenase | Tyrosine 3-monooxygenase, catalytic domain | Tyrosine 3-monooxygenase-like | Tyrosine 3-monooxygenase-like, ACT domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BBY7 | InterPro | 473 | ||||||||||
| UniProtKB:Q6IVB6 | InterPro | 471 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(th2:GAL4-VP16) |
|
| 1 | (4) | |
| Tg(th2:GCaMP5) |
|
| 1 | (2) | |
| Tg(th2:GFP-Aequorin) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260P3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001829 (1) | 1635 nt | ||
| Genomic | GenBank:BX511171 (1) | 166242 nt | ||
| Polypeptide | UniProtKB:A0A8M2BBY7 (1) | 473 aa |
No data available
- Nies, Y.H., Lim, W.L., Abd Karim, N., Yahaya, M.F., Teoh, S.L. (2025) Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson's disease. Frontiers in pharmacology. 16:14780131478013
- Rajeswari, J.J., Gilbert, G.N.Y., Khalid, E., Vijayan, M.M. (2025) Brain monoamine changes modulate the corticotropin-releasing hormone receptor 1-mediated behavioural response to acute thermal stress in zebrafish larvae. Molecular and Cellular Endocrinology. :112494112494
- Tagkalidou, N., Stevanović, M., Romero-Alfano, I., Elizalde-Velázquez, G.A., Herrera-Vázquez, S.E., Prats, E., Gómez-Canela, C., Gómez-Oliván, L.M., Raldúa, D. (2025) Motor and Non-Motor Effects of Acute MPTP in Adult Zebrafish: Insights into Parkinson's Disease. International Journal of Molecular Sciences. 26:
- Baker, C.E., Marta, A.G., Zimmerman, N.D., Korade, Z., Mathy, N.W., Wilton, D., Simeone, T., Kochvar, A., Kramer, K.L., Stessman, H.A.F., Shibata, A. (2024) CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 14(8):
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Correia, D., Bellot, M., Goyenechea, J., Prats, E., Moro, H., Gómez-Canela, C., Bedrossiantz, J., Tagkalidou, N., Ferreira, C.S.S., Raldúa, D., Domingues, I., Faria, M., Oliveira, M. (2024) Parental exposure to antidepressants has lasting effects on offspring? A case study with zebrafish. Chemosphere. 355:141851
- Kim, T.Y., Roychaudhury, A., Kim, H.T., Choi, T.I., Baek, S.T., Thyme, S.B., Kim, C.H. (2024) Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536. Translational psychiatry. 14:8282
- Miyazaki, S., Shimizu, N., Miyahara, H., Teranishi, H., Umeda, R., Yano, S., Shimada, T., Shiraishi, H., Komiya, K., Katoh, A., Yoshimura, A., Hanada, R., Hanada, T. (2024) DHCR7 links cholesterol synthesis with neuronal development and axonal integrity. Biochemical and Biophysical Research Communications. 712-713:149932149932
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
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