Gene

th2

ID
ZDB-GENE-050201-1
Name
tyrosine hydroxylase 2
Symbol
th2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Enables tryptophan 5-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and serotonin biosynthetic process. Predicted to be located in neuron projection and perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in female organism; head; kidney; liver; and nervous system.
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
39 figures from 28 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-th2N/A (2)
MO2-th2N/ARen et al., 2013
MO3-th2N/ARen et al., 2013
MO4-th2N/A (2)
MO5-th2N/A (2)
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Human Disease
Associated With th2 Human Ortholog
No data available
Associated With th2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
Domain IPR019774 Aromatic amino acid hydroxylase, C-terminal
Domain IPR041903 Tyrosine 3-monooxygenase, catalytic domain
Domain IPR049321 Tyrosine 3-monooxygenase-like, ACT domain
Family IPR001273 Aromatic amino acid hydroxylase
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Domain Details Per Protein
Protein Additional Resources Length ACT-like domain Aromatic amino acid hydroxylase Aromatic amino acid hydroxylase, C-terminal Aromatic amino acid hydroxylase, iron/copper binding site Aromatic amino acid hydroxylase superfamily Aromatic amino acid monoxygenase, C-terminal domain superfamily Tyrosine 3-monooxygenase Tyrosine 3-monooxygenase, catalytic domain Tyrosine 3-monooxygenase-like Tyrosine 3-monooxygenase-like, ACT domain
UniProtKB:A0A8M2BBY7 InterPro 473
UniProtKB:Q6IVB6 InterPro 471
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 4
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA th2-201 (1) Ensembl 1,635 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
ab8-th Rabbit
  • WB
1
ab7-th IgY Chicken
  • IHC
  • WB
3
Ab4-th polyclonal Rabbit
  • IHC
  • WB
Millipore
50
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(th2:GAL4-VP16)
  • th2
  • Danio rerio
1 (4)
Tg(th2:GCaMP5)
  • th2
  • Danio rerio
1 (2)
Tg(th2:GFP-Aequorin)
  • th2
  • Danio rerio
1 (4)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-260P3ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations
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