ZFIN ID: ZDB-FIG-120329-37
Zhu et al., 2012 - Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis. Cancer Cell   21(3):362-373 Full text @ Cancer Cell
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Term:
Stage Range: Long-pec to Protruding-mouth

Fig. 5

Expression of Early Sympathoadrenal Markers Is Absent in MYCN Transgenic Embryos during Early Development (A and B) Top panels: DβH; lower panels: MYCN transgenic fish. Expression of sympathoadrenal cell markers at 54 hpf (A) and 80 hpf (B). The magnified view of the boxed region is shown on the right. Arrows point to the superior cervical ganglion. Scale bars represent 50 μm (left panels) and 100 μm (right panels, magnified view). (C) Diagram of the genetic interactions of sympathoadrenal genes during early development. Arrows indicate the activation of target genes. Curved arrows indicate positive feedback regulation. See also Figure S5.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
ascl1a zdf15Tg (AB) standard conditions Long-pec superior cervical ganglion ISH
zdf16Tg (AB) standard conditions Long-pec Not Detected superior cervical ganglion ISH
phox2bb zdf15Tg (AB) standard conditions Long-pec superior cervical ganglion ISH
Protruding-mouth superior cervical ganglion ISH
zdf16Tg (AB) standard conditions Long-pec Not Detected superior cervical ganglion ISH
Protruding-mouth Not Detected superior cervical ganglion ISH
tfap2a zdf15Tg (AB) standard conditions Long-pec superior cervical ganglion ISH
Protruding-mouth superior cervical ganglion ISH
zdf16Tg (AB) standard conditions Long-pec Not Detected superior cervical ganglion ISH
Protruding-mouth Not Detected superior cervical ganglion ISH
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
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Reprinted from Cancer Cell, 21(3), Zhu, S., Lee, J.S., Guo, F., Shin, J., Perez-Atayde, A.R., Kutok, J.L., Rodig, S.J., Neuberg, D.S., Helman, D., Feng, H., Stewart, R.A., Wang, W., George, R.E., Kanki, J.P., and Look, A.T., Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis, 362-373, Copyright (2012) with permission from Elsevier. Full text @ Cancer Cell