ZFIN Figure: Zhu et al., 2012, Fig. 5

ZFIN ID: ZDB-FIG-120329-37

ZFIN ID: ZDB-FIG-120329-37

Zhu et al., 2012 - Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis. Cancer Cell 21(3):362-373 Full text @ Cancer Cell

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Genes:	ascl1a phox2bb tfap2a
Fish:	zdf15Tg (AB) zdf16Tg (AB)
Anatomical Term:	superior cervical ganglion
Stage Range:	Long-pec to Protruding-mouth

Fig. 5

Expression of Early Sympathoadrenal Markers Is Absent in MYCN Transgenic Embryos during Early Development (A and B) Top panels: DβH; lower panels: MYCN transgenic fish. Expression of sympathoadrenal cell markers at 54 hpf (A) and 80 hpf (B). The magnified view of the boxed region is shown on the right. Arrows point to the superior cervical ganglion. Scale bars represent 50 μm (left panels) and 100 μm (right panels, magnified view). (C) Diagram of the genetic interactions of sympathoadrenal genes during early development. Arrows indicate the activation of target genes. Curved arrows indicate positive feedback regulation. See also Figure S5.

Gene Expression Details

Gene	Fish	Conditions	Stage	Qualifier	Anatomy	Assay
ascl1a	zdf15Tg (AB)	standard conditions	Long-pec		superior cervical ganglion	ISH
	zdf16Tg (AB)	standard conditions	Long-pec	Not Detected	superior cervical ganglion	ISH
phox2bb	zdf15Tg (AB)	standard conditions	Long-pec		superior cervical ganglion	ISH
			Protruding-mouth		superior cervical ganglion	ISH
	zdf16Tg (AB)	standard conditions	Long-pec	Not Detected	superior cervical ganglion	ISH
			Protruding-mouth	Not Detected	superior cervical ganglion	ISH
tfap2a	zdf15Tg (AB)	standard conditions	Long-pec		superior cervical ganglion	ISH
			Protruding-mouth		superior cervical ganglion	ISH
	zdf16Tg (AB)	standard conditions	Long-pec	Not Detected	superior cervical ganglion	ISH
			Protruding-mouth	Not Detected	superior cervical ganglion	ISH

Antibody Labeling Details No data available

Phenotype Details No data available

Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Reprinted from Cancer Cell, 21(3), Zhu, S., Lee, J.S., Guo, F., Shin, J., Perez-Atayde, A.R., Kutok, J.L., Rodig, S.J., Neuberg, D.S., Helman, D., Feng, H., Stewart, R.A., Wang, W., George, R.E., Kanki, J.P., and Look, A.T., Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis, 362-373, Copyright (2012) with permission from Elsevier. Full text @ Cancer Cell

Acknowledgments:

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Cancer Cell, 21(3), Zhu, S., Lee, J.S., Guo, F., Shin, J., Perez-Atayde, A.R., Kutok, J.L., Rodig, S.J., Neuberg, D.S., Helman, D., Feng, H., Stewart, R.A., Wang, W., George, R.E., Kanki, J.P., and Look, A.T., Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis, 362-373, Copyright (2012) with permission from Elsevier. Full text @ Cancer Cell